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Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration

BACKGROUND: The aim of this study was to analyze the relationship of the estimated glomerular filtration rate (eGFR) to hydroxychloroquine (HCQ) blood concentrations in systemic lupus erythematosus (SLE) patients. METHOD: Patients with SLE who had been taking HCQ for more than 12 months were recruit...

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Autores principales: Zhong, Xue, Jin, Yue-bo, Zhang, Qin, Liu, Si-lu, He, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267264/
https://www.ncbi.nlm.nih.gov/pubmed/36939974
http://dx.doi.org/10.1007/s10067-023-06576-x
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author Zhong, Xue
Jin, Yue-bo
Zhang, Qin
Liu, Si-lu
He, Jing
author_facet Zhong, Xue
Jin, Yue-bo
Zhang, Qin
Liu, Si-lu
He, Jing
author_sort Zhong, Xue
collection PubMed
description BACKGROUND: The aim of this study was to analyze the relationship of the estimated glomerular filtration rate (eGFR) to hydroxychloroquine (HCQ) blood concentrations in systemic lupus erythematosus (SLE) patients. METHOD: Patients with SLE who had been taking HCQ for more than 12 months were recruited. All subjects gave written informed consent. Various clinical characteristics and laboratory values were examined. The blood concentration of HCQ was measured by high-performance liquid chromatography, and the relationship of eGFR to HCQ blood concentration was mainly investigated. RESULT: In total, 115 patients with SLE receiving long-term HCQ therapy were included in the study. The median concentration of HCQ was 1096 ng/ml (range 116–8240 ng/ml). The eGFR was strongly associated with blood concentration of HCQ (P = 0.011, P < 0.05), when adjusted for age, sex, body mass index (BMI), weight-adjusted dose, prednisone use and immunosuppressive drug use. No statistically significant association were found between age, duration, BMI, weight-adjusted HCQ dose, corticosteroid use, immunosuppressant use and blood concentrations of HCQ. CONCLUSION: We provided novel evidence that impaired renal function influenced the blood concentration of HCQ. Patients with low eGFR need to adjust the HCQ dosage according to the monitoring results of HCQ blood concentrations.
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spelling pubmed-102672642023-06-15 Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration Zhong, Xue Jin, Yue-bo Zhang, Qin Liu, Si-lu He, Jing Clin Rheumatol Original Article BACKGROUND: The aim of this study was to analyze the relationship of the estimated glomerular filtration rate (eGFR) to hydroxychloroquine (HCQ) blood concentrations in systemic lupus erythematosus (SLE) patients. METHOD: Patients with SLE who had been taking HCQ for more than 12 months were recruited. All subjects gave written informed consent. Various clinical characteristics and laboratory values were examined. The blood concentration of HCQ was measured by high-performance liquid chromatography, and the relationship of eGFR to HCQ blood concentration was mainly investigated. RESULT: In total, 115 patients with SLE receiving long-term HCQ therapy were included in the study. The median concentration of HCQ was 1096 ng/ml (range 116–8240 ng/ml). The eGFR was strongly associated with blood concentration of HCQ (P = 0.011, P < 0.05), when adjusted for age, sex, body mass index (BMI), weight-adjusted dose, prednisone use and immunosuppressive drug use. No statistically significant association were found between age, duration, BMI, weight-adjusted HCQ dose, corticosteroid use, immunosuppressant use and blood concentrations of HCQ. CONCLUSION: We provided novel evidence that impaired renal function influenced the blood concentration of HCQ. Patients with low eGFR need to adjust the HCQ dosage according to the monitoring results of HCQ blood concentrations. Springer International Publishing 2023-03-20 2023 /pmc/articles/PMC10267264/ /pubmed/36939974 http://dx.doi.org/10.1007/s10067-023-06576-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhong, Xue
Jin, Yue-bo
Zhang, Qin
Liu, Si-lu
He, Jing
Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title_full Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title_fullStr Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title_full_unstemmed Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title_short Low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
title_sort low estimated glomerular filtration rate is an independent risk factor for higher hydroxychloroquine concentration
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267264/
https://www.ncbi.nlm.nih.gov/pubmed/36939974
http://dx.doi.org/10.1007/s10067-023-06576-x
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