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Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities

BACKGROUND: Bulbar dysfunction is a cardinal feature of ALS with important quality of life and management implications. The objective of this study is the longitudinal evaluation of a large panel imaging metrics pertaining to bulbar dysfunction, encompassing cortical measures, structural and functio...

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Detalles Bibliográficos
Autores principales:	Tahedl, Marlene, Tan, Ee Ling, Chipika, Rangariroyashe H., Hengeveld, Jennifer C., Vajda, Alice, Doherty, Mark A., McLaughlin, Russell L., Siah, We Fong, Hardiman, Orla, Bede, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Original Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267265/ https://www.ncbi.nlm.nih.gov/pubmed/37022479 http://dx.doi.org/10.1007/s00415-023-11682-6

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