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Lenacapavir: First Approval

Lenacapavir (Sunlenca(®)) is a long-acting capsid inhibitor of human immunodeficiency virus type 1 (HIV-1) being developed by Gilead Sciences Inc. It is available as an oral tablet and injectable solution, with the latter being a slow-release formulation to allow bi-annual subcutaneous administratio...

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Detalles Bibliográficos
Autor principal: Paik, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267266/
https://www.ncbi.nlm.nih.gov/pubmed/36272024
http://dx.doi.org/10.1007/s40265-022-01786-0
Descripción
Sumario:Lenacapavir (Sunlenca(®)) is a long-acting capsid inhibitor of human immunodeficiency virus type 1 (HIV-1) being developed by Gilead Sciences Inc. It is available as an oral tablet and injectable solution, with the latter being a slow-release formulation to allow bi-annual subcutaneous administration. In August 2022, lenacapavir received its first approval in the EU for use in combination with other antiretroviral(s) in adults with multi-drug resistant HIV infection, for whom it is otherwise not possible to construct a suppressive anti-viral regimen. This article summarizes the milestones in the development of lenacapavir leading to this first approval for the treatment of HIV-1 infection. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40265-022-01786-0.