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Toeing the line between regeneration and fibrosis
Understanding the remarkable capacity of vertebrates to naturally regenerate injured body parts has great importance for potential translation into human therapeutic applications. As compared to other vertebrates, mammals have low regenerative capacity for composite tissues like the limb. However, s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267333/ https://www.ncbi.nlm.nih.gov/pubmed/37325560 http://dx.doi.org/10.3389/fcell.2023.1217185 |
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author | Jou, Vivian Lehoczky, Jessica A. |
author_facet | Jou, Vivian Lehoczky, Jessica A. |
author_sort | Jou, Vivian |
collection | PubMed |
description | Understanding the remarkable capacity of vertebrates to naturally regenerate injured body parts has great importance for potential translation into human therapeutic applications. As compared to other vertebrates, mammals have low regenerative capacity for composite tissues like the limb. However, some primates and rodents can regenerate the distal tips of their digits following amputation, indicating that at least very distal mammalian limb tissues are competent for innate regeneration. It follows that successful digit tip regenerative outcome is highly dependent on the location of the amputation; those proximal to the position of the nail organ do not regenerate and result in fibrosis. This distal regeneration versus proximal fibrosis duality of the mouse digit tip serves as a powerful model to investigate the driving factors in determining each process. In this review, we present the current understanding of distal digit tip regeneration in the context of cellular heterogeneity and the potential for different cell types to function as progenitor cells, in pro-regenerative signaling, or in moderating fibrosis. We then go on to discuss these themes in the context of what is known about proximal digit fibrosis, towards generating hypotheses for these distinct healing processes in the distal and proximal mouse digit. |
format | Online Article Text |
id | pubmed-10267333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102673332023-06-15 Toeing the line between regeneration and fibrosis Jou, Vivian Lehoczky, Jessica A. Front Cell Dev Biol Cell and Developmental Biology Understanding the remarkable capacity of vertebrates to naturally regenerate injured body parts has great importance for potential translation into human therapeutic applications. As compared to other vertebrates, mammals have low regenerative capacity for composite tissues like the limb. However, some primates and rodents can regenerate the distal tips of their digits following amputation, indicating that at least very distal mammalian limb tissues are competent for innate regeneration. It follows that successful digit tip regenerative outcome is highly dependent on the location of the amputation; those proximal to the position of the nail organ do not regenerate and result in fibrosis. This distal regeneration versus proximal fibrosis duality of the mouse digit tip serves as a powerful model to investigate the driving factors in determining each process. In this review, we present the current understanding of distal digit tip regeneration in the context of cellular heterogeneity and the potential for different cell types to function as progenitor cells, in pro-regenerative signaling, or in moderating fibrosis. We then go on to discuss these themes in the context of what is known about proximal digit fibrosis, towards generating hypotheses for these distinct healing processes in the distal and proximal mouse digit. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10267333/ /pubmed/37325560 http://dx.doi.org/10.3389/fcell.2023.1217185 Text en Copyright © 2023 Jou and Lehoczky. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Jou, Vivian Lehoczky, Jessica A. Toeing the line between regeneration and fibrosis |
title | Toeing the line between regeneration and fibrosis |
title_full | Toeing the line between regeneration and fibrosis |
title_fullStr | Toeing the line between regeneration and fibrosis |
title_full_unstemmed | Toeing the line between regeneration and fibrosis |
title_short | Toeing the line between regeneration and fibrosis |
title_sort | toeing the line between regeneration and fibrosis |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267333/ https://www.ncbi.nlm.nih.gov/pubmed/37325560 http://dx.doi.org/10.3389/fcell.2023.1217185 |
work_keys_str_mv | AT jouvivian toeingthelinebetweenregenerationandfibrosis AT lehoczkyjessicaa toeingthelinebetweenregenerationandfibrosis |