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Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer

Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC). Methods: We constructed 17 patient-derived xenograft (PDX) models from PDAC patient samples and identified the most notable responder to gemcitabine by screeni...

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Detalles Bibliográficos
Autores principales:	Hou, Zelin, Lin, Jiajing, Ma, Yuan, Fang, Haizhong, Wu, Yuwei, Chen, Zhijiang, Lin, Xianchao, Lu, Fengchun, Wen, Shi, Yu, Xunbin, Huang, Heguang, Pan, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267405/ https://www.ncbi.nlm.nih.gov/pubmed/37324492 http://dx.doi.org/10.3389/fphar.2023.1193791

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