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Hydroxyurea pharmacokinetics and precision dosing in low-resource settings

Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits without additional toxicities, but requires dose adjustments with serial monitoring. Pharmacokinetic (PK)-guided dosing can predict a...

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Detalles Bibliográficos
Autores principales:	Smart, Luke R., Charles, Mwesige, McElhinney, Kathryn E., Dong, Min, Power-Hays, Alexandra, Howard, Thad, Vinks, Alexander A., Ambrose, Emmanuela E., Ware, Russell E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267409/ https://www.ncbi.nlm.nih.gov/pubmed/37325474 http://dx.doi.org/10.3389/fmolb.2023.1130206

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