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Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells
APOBEC3 (A3) enzymes deaminate cytosine to uracil in viral single-stranded DNA as a mutagenic barrier for some viruses. A3-induced deaminations can also occur in human genomes resulting in an endogenous source of somatic mutations in multiple cancers. However, the roles of each A3 are unclear since...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267419/ https://www.ncbi.nlm.nih.gov/pubmed/37324648 http://dx.doi.org/10.3389/fgeed.2023.1196697 |