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Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions

Introduction: The application of neuromuscular electrical stimulation superimposed on voluntary muscle contractions (NMES+) has demonstrated a considerable potential to enhance or restore muscle function in both healthy and individuals with neurological or orthopedic disorders. Improvements in muscl...

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Autores principales: Borzuola, Riccardo, Nuccio, Stefano, Scalia, Martina, Parrella, Martina, Del Vecchio, Alessandro, Bazzucchi, Ilenia, Felici, Francesco, Macaluso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267458/
https://www.ncbi.nlm.nih.gov/pubmed/37324379
http://dx.doi.org/10.3389/fphys.2023.1212453
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author Borzuola, Riccardo
Nuccio, Stefano
Scalia, Martina
Parrella, Martina
Del Vecchio, Alessandro
Bazzucchi, Ilenia
Felici, Francesco
Macaluso, Andrea
author_facet Borzuola, Riccardo
Nuccio, Stefano
Scalia, Martina
Parrella, Martina
Del Vecchio, Alessandro
Bazzucchi, Ilenia
Felici, Francesco
Macaluso, Andrea
author_sort Borzuola, Riccardo
collection PubMed
description Introduction: The application of neuromuscular electrical stimulation superimposed on voluntary muscle contractions (NMES+) has demonstrated a considerable potential to enhance or restore muscle function in both healthy and individuals with neurological or orthopedic disorders. Improvements in muscle strength and power have been commonly associated with specific neural adaptations. In this study, we investigated changes in the discharge characteristics of the tibialis anterior motor units, following three acute exercises consisting of NMES+, passive NMES and voluntary isometric contractions alone. Methods: Seventeen young participants participated in the study. High-density surface electromyography was used to record myoelectric activity in the tibialis anterior muscle during trapezoidal force trajectories involving isometric contractions of ankle dorsi flexors with target forces set at 35, 50% and 70% of maximal voluntary isometric contraction (MVIC). From decomposition of the electromyographic signal, motor unit discharge rate, recruitment and derecruitment thresholds were extracted and the input-output gain of the motoneuron pool was estimated. Results: Global discharge rate increased following the isometric condition compared to baseline at 35% MVIC while it increased after all experimental conditions at 50% MVIC target force. Interestingly, at 70% MVIC target force, only NMES + led to greater discharge rate compared to baseline. Recruitment threshold decreased after the isometric condition, although only at 50% MVIC. Input-output gain of the motoneurons of the tibialis anterior muscle was unaltered after the experimental conditions. Discussion: These results indicated that acute exercise involving NMES + induces an increase in motor unit discharge rate, particularly when higher forces are required. This reflects an enhanced neural drive to the muscle and might be strongly related to the distinctive motor fiber recruitment characterizing NMES+.
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spelling pubmed-102674582023-06-15 Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions Borzuola, Riccardo Nuccio, Stefano Scalia, Martina Parrella, Martina Del Vecchio, Alessandro Bazzucchi, Ilenia Felici, Francesco Macaluso, Andrea Front Physiol Physiology Introduction: The application of neuromuscular electrical stimulation superimposed on voluntary muscle contractions (NMES+) has demonstrated a considerable potential to enhance or restore muscle function in both healthy and individuals with neurological or orthopedic disorders. Improvements in muscle strength and power have been commonly associated with specific neural adaptations. In this study, we investigated changes in the discharge characteristics of the tibialis anterior motor units, following three acute exercises consisting of NMES+, passive NMES and voluntary isometric contractions alone. Methods: Seventeen young participants participated in the study. High-density surface electromyography was used to record myoelectric activity in the tibialis anterior muscle during trapezoidal force trajectories involving isometric contractions of ankle dorsi flexors with target forces set at 35, 50% and 70% of maximal voluntary isometric contraction (MVIC). From decomposition of the electromyographic signal, motor unit discharge rate, recruitment and derecruitment thresholds were extracted and the input-output gain of the motoneuron pool was estimated. Results: Global discharge rate increased following the isometric condition compared to baseline at 35% MVIC while it increased after all experimental conditions at 50% MVIC target force. Interestingly, at 70% MVIC target force, only NMES + led to greater discharge rate compared to baseline. Recruitment threshold decreased after the isometric condition, although only at 50% MVIC. Input-output gain of the motoneurons of the tibialis anterior muscle was unaltered after the experimental conditions. Discussion: These results indicated that acute exercise involving NMES + induces an increase in motor unit discharge rate, particularly when higher forces are required. This reflects an enhanced neural drive to the muscle and might be strongly related to the distinctive motor fiber recruitment characterizing NMES+. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10267458/ /pubmed/37324379 http://dx.doi.org/10.3389/fphys.2023.1212453 Text en Copyright © 2023 Borzuola, Nuccio, Scalia, Parrella, Del Vecchio, Bazzucchi, Felici and Macaluso. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Borzuola, Riccardo
Nuccio, Stefano
Scalia, Martina
Parrella, Martina
Del Vecchio, Alessandro
Bazzucchi, Ilenia
Felici, Francesco
Macaluso, Andrea
Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title_full Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title_fullStr Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title_full_unstemmed Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title_short Adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
title_sort adjustments in the motor unit discharge behavior following neuromuscular electrical stimulation compared to voluntary contractions
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267458/
https://www.ncbi.nlm.nih.gov/pubmed/37324379
http://dx.doi.org/10.3389/fphys.2023.1212453
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