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Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health

BACKGROUND: Frailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older ad...

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Autores principales: García-Chanes, Rosa Estela, Avila-Funes, José Alberto, Borda, Miguel Germán, Pérez-Zepeda, Mario Ulises, Gutiérrez-Robledo, Luis Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267459/
https://www.ncbi.nlm.nih.gov/pubmed/37324127
http://dx.doi.org/10.3389/fmed.2023.1166365
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author García-Chanes, Rosa Estela
Avila-Funes, José Alberto
Borda, Miguel Germán
Pérez-Zepeda, Mario Ulises
Gutiérrez-Robledo, Luis Miguel
author_facet García-Chanes, Rosa Estela
Avila-Funes, José Alberto
Borda, Miguel Germán
Pérez-Zepeda, Mario Ulises
Gutiérrez-Robledo, Luis Miguel
author_sort García-Chanes, Rosa Estela
collection PubMed
description BACKGROUND: Frailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries. METHODS: We analyzed the baseline the Study on Global Ageing and Adult Health (SAGE), that includes six countries (Ghana, South Africa, Mexico, China, Russia, and India). A cross-section analysis was used to assess how Frailty was related with the Clinical Frailty Scale decision tree, while cognitive decline was evaluated using standardized scores of tests used in SAGE. RESULTS: A total of 30,674 participants aged 50 years or older were included. There was an association between frailty levels and cognitive performance. For example, women had an inverse relationship between frailty levels and cognitive scores, even when comparing robust category with frailty level 2 (RRR = 0.85; p = 0.41), although the relative risks decrease significantly at level 3 (RRR = 0.66; p = 0.03). When controlling for age, the relative risks between frailty levels 4 to 7 significantly decreased as cognitive performance increased (RRR = 0.46, RRR = 0.52, RRR = 0.44, RRR = 0.32; p < 0.001). CONCLUSION: Our results show an association between frailty levels measured in a novel way, and cognitive decline across different cultural settings.
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spelling pubmed-102674592023-06-15 Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health García-Chanes, Rosa Estela Avila-Funes, José Alberto Borda, Miguel Germán Pérez-Zepeda, Mario Ulises Gutiérrez-Robledo, Luis Miguel Front Med (Lausanne) Medicine BACKGROUND: Frailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries. METHODS: We analyzed the baseline the Study on Global Ageing and Adult Health (SAGE), that includes six countries (Ghana, South Africa, Mexico, China, Russia, and India). A cross-section analysis was used to assess how Frailty was related with the Clinical Frailty Scale decision tree, while cognitive decline was evaluated using standardized scores of tests used in SAGE. RESULTS: A total of 30,674 participants aged 50 years or older were included. There was an association between frailty levels and cognitive performance. For example, women had an inverse relationship between frailty levels and cognitive scores, even when comparing robust category with frailty level 2 (RRR = 0.85; p = 0.41), although the relative risks decrease significantly at level 3 (RRR = 0.66; p = 0.03). When controlling for age, the relative risks between frailty levels 4 to 7 significantly decreased as cognitive performance increased (RRR = 0.46, RRR = 0.52, RRR = 0.44, RRR = 0.32; p < 0.001). CONCLUSION: Our results show an association between frailty levels measured in a novel way, and cognitive decline across different cultural settings. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10267459/ /pubmed/37324127 http://dx.doi.org/10.3389/fmed.2023.1166365 Text en Copyright © 2023 García-Chanes, Avila-Funes, Borda, Pérez-Zepeda and Gutiérrez-Robledo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
García-Chanes, Rosa Estela
Avila-Funes, José Alberto
Borda, Miguel Germán
Pérez-Zepeda, Mario Ulises
Gutiérrez-Robledo, Luis Miguel
Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title_full Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title_fullStr Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title_full_unstemmed Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title_short Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
title_sort higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267459/
https://www.ncbi.nlm.nih.gov/pubmed/37324127
http://dx.doi.org/10.3389/fmed.2023.1166365
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