Cargando…
Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health
Zebrafish (Danio rerio) have emerged as a powerful model to study the gut microbiome in the context of human conditions, including hypertension, cardiovascular disease, neurological disorders, and immune dysfunction. Here, we highlight zebrafish as a tool to bridge the gap in knowledge in linking th...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267477/ https://www.ncbi.nlm.nih.gov/pubmed/37324381 http://dx.doi.org/10.3389/fphys.2023.1186645 |
_version_ | 1785058937133858816 |
---|---|
author | Sree Kumar, Hemaa Wisner, Alexander S. Refsnider, Jeanine M. Martyniuk, Christopher J. Zubcevic, Jasenka |
author_facet | Sree Kumar, Hemaa Wisner, Alexander S. Refsnider, Jeanine M. Martyniuk, Christopher J. Zubcevic, Jasenka |
author_sort | Sree Kumar, Hemaa |
collection | PubMed |
description | Zebrafish (Danio rerio) have emerged as a powerful model to study the gut microbiome in the context of human conditions, including hypertension, cardiovascular disease, neurological disorders, and immune dysfunction. Here, we highlight zebrafish as a tool to bridge the gap in knowledge in linking the gut microbiome and physiological homeostasis of cardiovascular, neural, and immune systems, both independently and as an integrated axis. Drawing on zebrafish studies to date, we discuss challenges in microbiota transplant techniques and gnotobiotic husbandry practices. We present advantages and current limitations in zebrafish microbiome research and discuss the use of zebrafish in identification of microbial enterotypes in health and disease. We also highlight the versatility of zebrafish studies to further explore the function of human conditions relevant to gut dysbiosis and reveal novel therapeutic targets. |
format | Online Article Text |
id | pubmed-10267477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102674772023-06-15 Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health Sree Kumar, Hemaa Wisner, Alexander S. Refsnider, Jeanine M. Martyniuk, Christopher J. Zubcevic, Jasenka Front Physiol Physiology Zebrafish (Danio rerio) have emerged as a powerful model to study the gut microbiome in the context of human conditions, including hypertension, cardiovascular disease, neurological disorders, and immune dysfunction. Here, we highlight zebrafish as a tool to bridge the gap in knowledge in linking the gut microbiome and physiological homeostasis of cardiovascular, neural, and immune systems, both independently and as an integrated axis. Drawing on zebrafish studies to date, we discuss challenges in microbiota transplant techniques and gnotobiotic husbandry practices. We present advantages and current limitations in zebrafish microbiome research and discuss the use of zebrafish in identification of microbial enterotypes in health and disease. We also highlight the versatility of zebrafish studies to further explore the function of human conditions relevant to gut dysbiosis and reveal novel therapeutic targets. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10267477/ /pubmed/37324381 http://dx.doi.org/10.3389/fphys.2023.1186645 Text en Copyright © 2023 Sree Kumar, Wisner, Refsnider, Martyniuk and Zubcevic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Sree Kumar, Hemaa Wisner, Alexander S. Refsnider, Jeanine M. Martyniuk, Christopher J. Zubcevic, Jasenka Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title | Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title_full | Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title_fullStr | Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title_full_unstemmed | Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title_short | Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
title_sort | small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267477/ https://www.ncbi.nlm.nih.gov/pubmed/37324381 http://dx.doi.org/10.3389/fphys.2023.1186645 |
work_keys_str_mv | AT sreekumarhemaa smallfishbigdiscoverieszebrafishshedlightonmicrobialbiomarkersforneuroimmunecardiovascularhealth AT wisneralexanders smallfishbigdiscoverieszebrafishshedlightonmicrobialbiomarkersforneuroimmunecardiovascularhealth AT refsniderjeaninem smallfishbigdiscoverieszebrafishshedlightonmicrobialbiomarkersforneuroimmunecardiovascularhealth AT martyniukchristopherj smallfishbigdiscoverieszebrafishshedlightonmicrobialbiomarkersforneuroimmunecardiovascularhealth AT zubcevicjasenka smallfishbigdiscoverieszebrafishshedlightonmicrobialbiomarkersforneuroimmunecardiovascularhealth |