PD-1/CTLA-4 Blockade Leads to Expansion of CD8(+)PD-1(int) TILs and Results in Tumor Remission in Experimental Liver Cancer

BACKGROUND: Checkpoint inhibitors act on exhausted CD8<sup>+</sup> T cells and restore their effector function in chronic infections and cancer. The underlying mechanisms of action appear to differ between different types of cancer and are not yet fully understood. METHODS: Here, we esta...

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Detalles Bibliográficos
Autores principales: Bufe, Sandra, Zimmermann, Artur, Ravens, Sarina, Prinz, Immo, Buitrago-Molina, Laura Elisa, Geffers, Robert, Woller, Norman, Kühnel, Florian, Talbot, Steven R., Noyan, Fatih, Manns, Michael Peter, Wedemeyer, Heiner, Hardtke-Wolenski, Matthias, Jaeckel, Elmar, Davalos-Misslitz, Ana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267567/
https://www.ncbi.nlm.nih.gov/pubmed/37325488
http://dx.doi.org/10.1159/000526899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267567/
https://www.ncbi.nlm.nih.gov/pubmed/37325488
http://dx.doi.org/10.1159/000526899

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