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A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

It is unclear whether mitochondrial dysfunction and redox stress contribute to impaired age-related muscle regenerative capacity. Here we characterized a novel compound, BI4500, that inhibits the release of reactive oxygen species (ROS) from the quinone site in mitochondrial complex I (site I(Q)). W...

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Detalles Bibliográficos
Autores principales:	Pharaoh, Gavin, Ostrom, Ethan L., Stuppard, Rudy, Campbell, Matthew, Borghardt, Jens Markus, Franti, Michael, Filareto, Antonio, Marcinek, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267642/ https://www.ncbi.nlm.nih.gov/pubmed/37295159 http://dx.doi.org/10.1016/j.redox.2023.102770

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