Chi3l1 Is a Modulator of Glioma Stem Cell States and a Therapeutic Target in Glioblastoma

Chitinase 3–like 1 (Chi3l1) is a secreted protein that is highly expressed in glioblastoma. Here, we show that Chi3l1 alters the state of glioma stem cells (GSC) to support tumor growth. Exposure of patient-derived GSCs to Chi3l1 reduced the frequency of CD133(+)SOX2(+) cells and increased the CD44(...

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Detalles Bibliográficos
Autores principales: Guetta-Terrier, Charlotte, Karambizi, David, Akosman, Bedia, Zepecki, John P., Chen, Jia-Shu, Kamle, Suchitra, Fajardo, J. Eduardo, Fiser, Andras, Singh, Ritambhara, Toms, Steven A., Lee, Chun Geun, Elias, Jack A., Tapinos, Nikos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267676/
https://www.ncbi.nlm.nih.gov/pubmed/37101376
http://dx.doi.org/10.1158/0008-5472.CAN-21-3629

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