Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases

Metastases are hard to detect and treat, and they cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellular matrix (ECM) forms a major component of the tumor microenvironment in both primary and metastatic tumors,...

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Detalles Bibliográficos
Autores principales: Jailkhani, Noor, Clauser, Karl R., Mak, Howard H., Rickelt, Steffen, Tian, Chenxi, Whittaker, Charles A., Tanabe, Kenneth K., Purdy, Stephen R., Carr, Steven A., Hynes, Richard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267678/
https://www.ncbi.nlm.nih.gov/pubmed/37098922
http://dx.doi.org/10.1158/0008-5472.CAN-22-1532

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