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ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma

Tyrosine kinase inhibitors (TKI) that can suppress the VEGF signaling pathway and angiogenesis have been developed to impede the progression of malignant tumors and have been approved as first-line targeted agents for clear cell renal cell carcinoma (ccRCC). Dysregulation of lipid metabolism is a ma...

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Detalles Bibliográficos
Autores principales:	Sun, Yan, Zhu, Liang, Liu, Pian, Zhang, Huan, Guo, Feng, Jin, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Cancer Metabolism and Molecular Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267682/ https://www.ncbi.nlm.nih.gov/pubmed/37078777 http://dx.doi.org/10.1158/0008-5472.CAN-22-3105

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