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Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis

Ulcerative colitis (UC) is a chronic aspecific gut inflammatory disorder that primarily involves the recta and colons. It mostly presents as a long course of repeated attacks. This disease, characterized by intermittent diarrhoea, fecal blood, stomachache, and tenesmus, severely decreases the living...

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Autores principales: Lu, Qiang, Xie, Yuhong, Luo, Jingbin, Gong, Qihai, Li, Cailan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268007/
https://www.ncbi.nlm.nih.gov/pubmed/37324477
http://dx.doi.org/10.3389/fphar.2023.1168990
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author Lu, Qiang
Xie, Yuhong
Luo, Jingbin
Gong, Qihai
Li, Cailan
author_facet Lu, Qiang
Xie, Yuhong
Luo, Jingbin
Gong, Qihai
Li, Cailan
author_sort Lu, Qiang
collection PubMed
description Ulcerative colitis (UC) is a chronic aspecific gut inflammatory disorder that primarily involves the recta and colons. It mostly presents as a long course of repeated attacks. This disease, characterized by intermittent diarrhoea, fecal blood, stomachache, and tenesmus, severely decreases the living quality of sick persons. UC is difficult to heal, has a high recurrence rate, and is tightly related to the incidence of colon cancer. Although there are a number of drugs available for the suppression of colitis, the conventional therapy possesses certain limitations and severe adverse reactions. Thus, it is extremely required for safe and effective medicines for colitis, and naturally derived flavones exhibited huge prospects. This study focused on the advancement of naturally derived flavones from edible and pharmaceutical plants for treating colitis. The underlying mechanisms of natural-derived flavones in treating UC were closely linked to the regulation of enteric barrier function, immune-inflammatory responses, oxidative stress, gut microflora, and SCFAs production. The prominent effects and safety of natural-derived flavones make them promising candidate drugs for colitis treatment.
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spelling pubmed-102680072023-06-15 Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis Lu, Qiang Xie, Yuhong Luo, Jingbin Gong, Qihai Li, Cailan Front Pharmacol Pharmacology Ulcerative colitis (UC) is a chronic aspecific gut inflammatory disorder that primarily involves the recta and colons. It mostly presents as a long course of repeated attacks. This disease, characterized by intermittent diarrhoea, fecal blood, stomachache, and tenesmus, severely decreases the living quality of sick persons. UC is difficult to heal, has a high recurrence rate, and is tightly related to the incidence of colon cancer. Although there are a number of drugs available for the suppression of colitis, the conventional therapy possesses certain limitations and severe adverse reactions. Thus, it is extremely required for safe and effective medicines for colitis, and naturally derived flavones exhibited huge prospects. This study focused on the advancement of naturally derived flavones from edible and pharmaceutical plants for treating colitis. The underlying mechanisms of natural-derived flavones in treating UC were closely linked to the regulation of enteric barrier function, immune-inflammatory responses, oxidative stress, gut microflora, and SCFAs production. The prominent effects and safety of natural-derived flavones make them promising candidate drugs for colitis treatment. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10268007/ /pubmed/37324477 http://dx.doi.org/10.3389/fphar.2023.1168990 Text en Copyright © 2023 Lu, Xie, Luo, Gong and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lu, Qiang
Xie, Yuhong
Luo, Jingbin
Gong, Qihai
Li, Cailan
Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title_full Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title_fullStr Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title_full_unstemmed Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title_short Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
title_sort natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268007/
https://www.ncbi.nlm.nih.gov/pubmed/37324477
http://dx.doi.org/10.3389/fphar.2023.1168990
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