Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure–Property Relationship Modeling To Design Inhalable Therapeutics for Asthma Targeting CSF1R

[Image: see text] The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine-protein kinase that is a potential target for asthma therapeutics. We have applied a fragment-lead combination approach to identify small fragments that act synergistically with GW2580, a known inhibitor of CSF1R. Two f...

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Detalles Bibliográficos
Autores principales: Vaid, Tasneem M., Demissie, Robel, Kwon, Youngjin, Tran, Thao, Moon, Hyung-Geun, Villegas, José A., Park, Gye Young, Johnson, Michael E., Lee, Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268011/
https://www.ncbi.nlm.nih.gov/pubmed/37323402
http://dx.doi.org/10.1021/acsomega.3c00803

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