Fully synthetic platform to rapidly generate tetravalent bispecific nanobody–based immunoglobulins

Nanobodies bind a target antigen with a kinetic profile similar to a conventional antibody, but exist as a single heavy chain domain that can be readily multimerized to engage antigen via multiple interactions. Presently, most nanobodies are produced by immunizing camelids; however, platforms for an...

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Detalles Bibliográficos
Autores principales: Misson Mindrebo, Laetitia, Liu, Hejun, Ozorowski, Gabriel, Tran, Quoc, Woehl, Jordan, Khalek, Irene, Smith, Jessica M., Barman, Shawn, Zhao, Fangzhu, Keating, Celina, Limbo, Oliver, Verma, Megan, Liu, Jingjia, Stanfield, Robyn L., Zhu, Xueyong, Turner, Hannah L., Sok, Devin, Huang, Po-Ssu, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Jardine, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268213/
https://www.ncbi.nlm.nih.gov/pubmed/37276407
http://dx.doi.org/10.1073/pnas.2216612120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268213/
https://www.ncbi.nlm.nih.gov/pubmed/37276407
http://dx.doi.org/10.1073/pnas.2216612120

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