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Topological insights into the neural basis of flexible behavior

It is widely accepted that there is an inextricable link between neural computations, biological mechanisms, and behavior, but it is challenging to simultaneously relate all three. Here, we show that topological data analysis (TDA) provides an important bridge between these approaches to studying ho...

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Detalles Bibliográficos
Autores principales: Rouse, Tevin C., Ni, Amy M., Huang, Chengcheng, Cohen, Marlene R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268229/
https://www.ncbi.nlm.nih.gov/pubmed/37279273
http://dx.doi.org/10.1073/pnas.2219557120
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author Rouse, Tevin C.
Ni, Amy M.
Huang, Chengcheng
Cohen, Marlene R.
author_facet Rouse, Tevin C.
Ni, Amy M.
Huang, Chengcheng
Cohen, Marlene R.
author_sort Rouse, Tevin C.
collection PubMed
description It is widely accepted that there is an inextricable link between neural computations, biological mechanisms, and behavior, but it is challenging to simultaneously relate all three. Here, we show that topological data analysis (TDA) provides an important bridge between these approaches to studying how brains mediate behavior. We demonstrate that cognitive processes change the topological description of the shared activity of populations of visual neurons. These topological changes constrain and distinguish between competing mechanistic models, are connected to subjects’ performance on a visual change detection task, and, via a link with network control theory, reveal a tradeoff between improving sensitivity to subtle visual stimulus changes and increasing the chance that the subject will stray off task. These connections provide a blueprint for using TDA to uncover the biological and computational mechanisms by which cognition affects behavior in health and disease.
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spelling pubmed-102682292023-12-06 Topological insights into the neural basis of flexible behavior Rouse, Tevin C. Ni, Amy M. Huang, Chengcheng Cohen, Marlene R. Proc Natl Acad Sci U S A Biological Sciences It is widely accepted that there is an inextricable link between neural computations, biological mechanisms, and behavior, but it is challenging to simultaneously relate all three. Here, we show that topological data analysis (TDA) provides an important bridge between these approaches to studying how brains mediate behavior. We demonstrate that cognitive processes change the topological description of the shared activity of populations of visual neurons. These topological changes constrain and distinguish between competing mechanistic models, are connected to subjects’ performance on a visual change detection task, and, via a link with network control theory, reveal a tradeoff between improving sensitivity to subtle visual stimulus changes and increasing the chance that the subject will stray off task. These connections provide a blueprint for using TDA to uncover the biological and computational mechanisms by which cognition affects behavior in health and disease. National Academy of Sciences 2023-06-06 2023-06-13 /pmc/articles/PMC10268229/ /pubmed/37279273 http://dx.doi.org/10.1073/pnas.2219557120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Rouse, Tevin C.
Ni, Amy M.
Huang, Chengcheng
Cohen, Marlene R.
Topological insights into the neural basis of flexible behavior
title Topological insights into the neural basis of flexible behavior
title_full Topological insights into the neural basis of flexible behavior
title_fullStr Topological insights into the neural basis of flexible behavior
title_full_unstemmed Topological insights into the neural basis of flexible behavior
title_short Topological insights into the neural basis of flexible behavior
title_sort topological insights into the neural basis of flexible behavior
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268229/
https://www.ncbi.nlm.nih.gov/pubmed/37279273
http://dx.doi.org/10.1073/pnas.2219557120
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