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FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA

Major histocompatibility complex (MHC) class I and II molecules play critical roles in the activation and regulation of adaptive immunity through antigen presentation to CD8+ and CD4+ T cells, respectively. Strict regulation of MHC expression is critical for proper immune responses. CIITA (MHC class...

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Detalles Bibliográficos
Autores principales:	Kasuga, Yusuke, Ouda, Ryota, Watanabe, Masashi, Sun, Xin, Kimura, Miki, Hatakeyama, Shigetsugu, Kobayashi, Koichi S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268274/ https://www.ncbi.nlm.nih.gov/pubmed/37279268 http://dx.doi.org/10.1073/pnas.2218955120

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