Membrane vesicle delivery of a streptococcal M protein disrupts the blood–brain barrier by inducing autophagic endothelial cell death

M family proteins are critical virulence determinants of Streptococci. Streptococcus equi subsp. zooepidemicus (SEZ) are Group C streptococci that cause meningitis in animals and humans. SzM, the M protein of SEZ, has been linked to SEZ brain invasion. Here, we demonstrate that SzM is important in S...

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Detalles Bibliográficos
Autores principales: Pan, Fei, Zhu, Mingli, Liang, Ying, Yuan, Chen, Zhang, Yu, Wang, Yuchang, Fan, Hongjie, Waldor, Matthew K., Ma, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268326/
https://www.ncbi.nlm.nih.gov/pubmed/37276410
http://dx.doi.org/10.1073/pnas.2219435120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268326/
https://www.ncbi.nlm.nih.gov/pubmed/37276410
http://dx.doi.org/10.1073/pnas.2219435120

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