Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus

A hepatitis C virus (HCV) vaccine is urgently needed. Vaccine development has been hindered by HCV’s genetic diversity, particularly within the immunodominant hypervariable region 1 (HVR1). Here, we developed a strategy to elicit broadly neutralizing antibodies to HVR1, which had previously been con...

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Detalles Bibliográficos
Autores principales: Mosa, Alexander I., Campo, David S., Khudyakov, Yury, AbouHaidar, Mounir G., Gehring, Adam J., Zahoor, Atif, Ball, Jonathan K., Urbanowicz, Richard A., Feld, Jordan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268328/
https://www.ncbi.nlm.nih.gov/pubmed/37276424
http://dx.doi.org/10.1073/pnas.2220294120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268328/
https://www.ncbi.nlm.nih.gov/pubmed/37276424
http://dx.doi.org/10.1073/pnas.2220294120

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