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Polyvalent immunization elicits a synergistic broadly neutralizing immune response to hypervariable region 1 variants of hepatitis C virus

A hepatitis C virus (HCV) vaccine is urgently needed. Vaccine development has been hindered by HCV’s genetic diversity, particularly within the immunodominant hypervariable region 1 (HVR1). Here, we developed a strategy to elicit broadly neutralizing antibodies to HVR1, which had previously been con...

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Detalles Bibliográficos
Autores principales:	Mosa, Alexander I., Campo, David S., Khudyakov, Yury, AbouHaidar, Mounir G., Gehring, Adam J., Zahoor, Atif, Ball, Jonathan K., Urbanowicz, Richard A., Feld, Jordan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268328/ https://www.ncbi.nlm.nih.gov/pubmed/37276424 http://dx.doi.org/10.1073/pnas.2220294120

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