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Control of the injection velocity of embolic agents in embolization treatment

BACKGROUND: Embolization is a common treatment method for tumor-targeting, anti-organ hyper-function, and hemostasis. However, the injection of embolic agents largely depends on the experiences of doctors, and doctors need to work in an X-ray environment that hurts their health. Even for a well-trai...

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Autores principales: Ren, Dongcheng, Zhou, Bo, Li, Jiasheng, Guo, Shijie, Guo, Baolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268356/
https://www.ncbi.nlm.nih.gov/pubmed/37316898
http://dx.doi.org/10.1186/s12938-023-01126-7
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author Ren, Dongcheng
Zhou, Bo
Li, Jiasheng
Guo, Shijie
Guo, Baolei
author_facet Ren, Dongcheng
Zhou, Bo
Li, Jiasheng
Guo, Shijie
Guo, Baolei
author_sort Ren, Dongcheng
collection PubMed
description BACKGROUND: Embolization is a common treatment method for tumor-targeting, anti-organ hyper-function, and hemostasis. However, the injection of embolic agents largely depends on the experiences of doctors, and doctors need to work in an X-ray environment that hurts their health. Even for a well-trained doctor, complications such as ectopic embolism caused by excessive embolic agents are always inevitable. RESULTS: This paper established a flow control curve model for embolic injection based on local arterial pressure. The end-vessel network was simplified as a porous media. The hemodynamic changes at different injection velocities and embolization degrees were simulated and analyzed. Sponge, a typical porous medium, was used to simulate the blocking and accumulation of embolic agents by capillary networks in the in vitro experimental platform. CONCLUSIONS: The simulation and experimental results show that the local arterial pressure is closely related to the critical injection velocity of the embolic agent reflux at a certain degree of embolization. The feasibility of this method for an automatic embolic injection system is discussed. It is concluded that the model of the flow control curve of embolic injection can effectively reduce the risk of ectopic embolism and shorten the time of embolic injection. The clinical application of this model is of great value in reducing radiation exposure and improving the success rate of interventional embolization.
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spelling pubmed-102683562023-06-15 Control of the injection velocity of embolic agents in embolization treatment Ren, Dongcheng Zhou, Bo Li, Jiasheng Guo, Shijie Guo, Baolei Biomed Eng Online Research BACKGROUND: Embolization is a common treatment method for tumor-targeting, anti-organ hyper-function, and hemostasis. However, the injection of embolic agents largely depends on the experiences of doctors, and doctors need to work in an X-ray environment that hurts their health. Even for a well-trained doctor, complications such as ectopic embolism caused by excessive embolic agents are always inevitable. RESULTS: This paper established a flow control curve model for embolic injection based on local arterial pressure. The end-vessel network was simplified as a porous media. The hemodynamic changes at different injection velocities and embolization degrees were simulated and analyzed. Sponge, a typical porous medium, was used to simulate the blocking and accumulation of embolic agents by capillary networks in the in vitro experimental platform. CONCLUSIONS: The simulation and experimental results show that the local arterial pressure is closely related to the critical injection velocity of the embolic agent reflux at a certain degree of embolization. The feasibility of this method for an automatic embolic injection system is discussed. It is concluded that the model of the flow control curve of embolic injection can effectively reduce the risk of ectopic embolism and shorten the time of embolic injection. The clinical application of this model is of great value in reducing radiation exposure and improving the success rate of interventional embolization. BioMed Central 2023-06-15 /pmc/articles/PMC10268356/ /pubmed/37316898 http://dx.doi.org/10.1186/s12938-023-01126-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ren, Dongcheng
Zhou, Bo
Li, Jiasheng
Guo, Shijie
Guo, Baolei
Control of the injection velocity of embolic agents in embolization treatment
title Control of the injection velocity of embolic agents in embolization treatment
title_full Control of the injection velocity of embolic agents in embolization treatment
title_fullStr Control of the injection velocity of embolic agents in embolization treatment
title_full_unstemmed Control of the injection velocity of embolic agents in embolization treatment
title_short Control of the injection velocity of embolic agents in embolization treatment
title_sort control of the injection velocity of embolic agents in embolization treatment
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268356/
https://www.ncbi.nlm.nih.gov/pubmed/37316898
http://dx.doi.org/10.1186/s12938-023-01126-7
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