Young Sca-1(+) bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization

BACKGROUND: Polarization of microglia, the resident retinal immune cells, plays important roles in mediating both injury and repair responses post-retinal ischemia–reperfusion (I/R) injury, which is one of the main pathological mechanisms behind ganglion cell apoptosis. Aging could perturb microglia...

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Detalles Bibliográficos
Autores principales: Wang, Yuan, Qin, Wan-yun, Wang, Qi, Liu, Xin-na, Li, Xiang-hui, Ye, Xin-qi, Bai, Ying, Zhang, Yan, Liu, Pan, Wang, Xin-lin, Zhou, Yu-hang, Yuan, Hui-ping, Shao, Zheng-bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268362/
https://www.ncbi.nlm.nih.gov/pubmed/37322478
http://dx.doi.org/10.1186/s12951-023-01944-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268362/
https://www.ncbi.nlm.nih.gov/pubmed/37322478
http://dx.doi.org/10.1186/s12951-023-01944-w

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