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Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

BACKGROUND: Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, immune regulator, and neuronal survival factor that is shuttled to the lysosome...

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Detalles Bibliográficos
Autores principales:	Kurnellas, Michael, Mitra, Ananya, Schwabe, Tina, Paul, Robert, Arrant, Andrew E., Roberson, Erik D., Ward, Michael, Yeh, Felix, Long, Hua, Rosenthal, Arnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268535/ https://www.ncbi.nlm.nih.gov/pubmed/37322482 http://dx.doi.org/10.1186/s12967-023-04251-y

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