Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease

Astroglial dysfunction contributes to the pathogenesis of Huntington’s disease (HD), and glial replacement can ameliorate the disease course. To establish the topographic relationship of diseased astrocytes to medium spiny neuron (MSN) synapses in HD, we used 2-photon imaging to map the relationship...

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Detalles Bibliográficos
Autores principales: Villanueva, Carlos Benitez, Stephensen, Hans J. T., Mokso, Rajmund, Benraiss, Abdellatif, Sporring, Jon, Goldman, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268590/
https://www.ncbi.nlm.nih.gov/pubmed/37279261
http://dx.doi.org/10.1073/pnas.2210719120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268590/
https://www.ncbi.nlm.nih.gov/pubmed/37279261
http://dx.doi.org/10.1073/pnas.2210719120

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