Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung

Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways of the developing human lung and identified by the unique coexpression of SCGB3A2/SFTPB/CFTR. To functionally interrogate these cells, we apply a single-cell barcode-based lineage tracing method, called CellTagg...

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Detalles Bibliográficos
Autores principales: Conchola, Ansley S., Frum, Tristan, Xiao, Zhiwei, Hsu, Peggy P., Kaur, Kamika, Downey, Michael S., Hein, Renee F. C., Miller, Alyssa J., Tsai, Yu-Hwai, Wu, Angeline, Holloway, Emily M., Anand, Abhinav, Murthy, Preetish Kadur Lakshminarasimha, Glass, Ian, Tata, Purushothama R., Spence, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268599/
https://www.ncbi.nlm.nih.gov/pubmed/37279279
http://dx.doi.org/10.1073/pnas.2210113120

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