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Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study

AIMS AND BACKGROUND: Hepatic hydrothorax, which presents as an unexplained pleural effusion, is one of the important complications in patients with end-stage cirrhosis. It has a significant correlation with prognosis and mortality. The aim of this clinical study was to detect the risk factors for he...

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Autores principales: Bai, Xue, Liu, Xiaoyan, Shi, Yanhui, Li, Wenwen, Li, Qiang, Du, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268603/
https://www.ncbi.nlm.nih.gov/pubmed/37332757
http://dx.doi.org/10.3389/fmed.2023.1165604
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author Bai, Xue
Liu, Xiaoyan
Shi, Yanhui
Li, Wenwen
Li, Qiang
Du, Wenjun
author_facet Bai, Xue
Liu, Xiaoyan
Shi, Yanhui
Li, Wenwen
Li, Qiang
Du, Wenjun
author_sort Bai, Xue
collection PubMed
description AIMS AND BACKGROUND: Hepatic hydrothorax, which presents as an unexplained pleural effusion, is one of the important complications in patients with end-stage cirrhosis. It has a significant correlation with prognosis and mortality. The aim of this clinical study was to detect the risk factors for hepatic hydrothorax in patients with cirrhosis and to better understand potentially life-threatening complications. METHODS: Retrospectively, 978 cirrhotic patients who were hospitalized at the Shandong Public Health Clinical Center from 2013 to 2021 were involved in this study. They were divided into the observation group and the control group based on the presence of hepatic hydrothorax. The epidemiological, clinical, laboratory, and radiological characteristics of the patients were collected and analyzed. ROC curves were used to evaluate the forecasting ability of the candidate model. Furthermore, 487 cases in the experimental group were divided into left, right, and bilateral groups, and the data were analyzed. RESULTS: The patients in the observation group had a higher proportion of upper gastrointestinal bleeding (UGIB), a history of spleen surgery, and a higher model for end-stage liver disease (MELD) scores compared with the control group. The width of the portal vein (PVW) (P = 0.022), prothrombin activity (PTA) (P = 0.012), D-dimer (P = 0.010), immunoglobulin G (IgG) (P = 0.007), high-density lipoprotein cholesterol (HDL) (P = 0.022), and the MELD score were significantly associated with the occurrence of the hepatic hydrothorax. The AUC of the candidate model was 0.805 (P < 0.001, 95% CI = 0.758–0.851). Portal vein thrombosis was more common in bilateral pleural effusion compared with the left and right sides (P = 0.018). CONCLUSION: The occurrence of hepatic hydrothorax has a close relationship with lower HDL, PTA, and higher PVW, D-dimer, IgG, and MELD scores. Portal vein thrombosis is more common in cirrhotic patients with bilateral pleural effusion compared to those with unilateral pleural effusion.
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spelling pubmed-102686032023-06-16 Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study Bai, Xue Liu, Xiaoyan Shi, Yanhui Li, Wenwen Li, Qiang Du, Wenjun Front Med (Lausanne) Medicine AIMS AND BACKGROUND: Hepatic hydrothorax, which presents as an unexplained pleural effusion, is one of the important complications in patients with end-stage cirrhosis. It has a significant correlation with prognosis and mortality. The aim of this clinical study was to detect the risk factors for hepatic hydrothorax in patients with cirrhosis and to better understand potentially life-threatening complications. METHODS: Retrospectively, 978 cirrhotic patients who were hospitalized at the Shandong Public Health Clinical Center from 2013 to 2021 were involved in this study. They were divided into the observation group and the control group based on the presence of hepatic hydrothorax. The epidemiological, clinical, laboratory, and radiological characteristics of the patients were collected and analyzed. ROC curves were used to evaluate the forecasting ability of the candidate model. Furthermore, 487 cases in the experimental group were divided into left, right, and bilateral groups, and the data were analyzed. RESULTS: The patients in the observation group had a higher proportion of upper gastrointestinal bleeding (UGIB), a history of spleen surgery, and a higher model for end-stage liver disease (MELD) scores compared with the control group. The width of the portal vein (PVW) (P = 0.022), prothrombin activity (PTA) (P = 0.012), D-dimer (P = 0.010), immunoglobulin G (IgG) (P = 0.007), high-density lipoprotein cholesterol (HDL) (P = 0.022), and the MELD score were significantly associated with the occurrence of the hepatic hydrothorax. The AUC of the candidate model was 0.805 (P < 0.001, 95% CI = 0.758–0.851). Portal vein thrombosis was more common in bilateral pleural effusion compared with the left and right sides (P = 0.018). CONCLUSION: The occurrence of hepatic hydrothorax has a close relationship with lower HDL, PTA, and higher PVW, D-dimer, IgG, and MELD scores. Portal vein thrombosis is more common in cirrhotic patients with bilateral pleural effusion compared to those with unilateral pleural effusion. Frontiers Media S.A. 2023-06-01 /pmc/articles/PMC10268603/ /pubmed/37332757 http://dx.doi.org/10.3389/fmed.2023.1165604 Text en Copyright © 2023 Bai, Liu, Shi, Li, Li and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Bai, Xue
Liu, Xiaoyan
Shi, Yanhui
Li, Wenwen
Li, Qiang
Du, Wenjun
Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title_full Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title_fullStr Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title_full_unstemmed Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title_short Risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
title_sort risk factors for hepatic hydrothorax in patients with cirrhosis: a clinical retrospective study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10268603/
https://www.ncbi.nlm.nih.gov/pubmed/37332757
http://dx.doi.org/10.3389/fmed.2023.1165604
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