Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistan...

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Autores principales: Hall, Carina M., Somprasong, Nawarat, Hagen, Johannah P., Nottingham, Roxanne, Sahl, Jason W., Webb, Jessica R., Mayo, Mark, Currie, Bart J., Podin, Yuwana, Wagner, David M., Keim, Paul, Schweizer, Herbert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269091/
https://www.ncbi.nlm.nih.gov/pubmed/37133377
http://dx.doi.org/10.1128/aac.00171-23
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author Hall, Carina M.
Somprasong, Nawarat
Hagen, Johannah P.
Nottingham, Roxanne
Sahl, Jason W.
Webb, Jessica R.
Mayo, Mark
Currie, Bart J.
Podin, Yuwana
Wagner, David M.
Keim, Paul
Schweizer, Herbert P.
author_facet Hall, Carina M.
Somprasong, Nawarat
Hagen, Johannah P.
Nottingham, Roxanne
Sahl, Jason W.
Webb, Jessica R.
Mayo, Mark
Currie, Bart J.
Podin, Yuwana
Wagner, David M.
Keim, Paul
Schweizer, Herbert P.
author_sort Hall, Carina M.
collection PubMed
description Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.
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spelling pubmed-102690912023-06-16 Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei Hall, Carina M. Somprasong, Nawarat Hagen, Johannah P. Nottingham, Roxanne Sahl, Jason W. Webb, Jessica R. Mayo, Mark Currie, Bart J. Podin, Yuwana Wagner, David M. Keim, Paul Schweizer, Herbert P. Antimicrob Agents Chemother Mechanisms of Resistance Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia. American Society for Microbiology 2023-05-03 /pmc/articles/PMC10269091/ /pubmed/37133377 http://dx.doi.org/10.1128/aac.00171-23 Text en Copyright © 2023 Hall et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Hall, Carina M.
Somprasong, Nawarat
Hagen, Johannah P.
Nottingham, Roxanne
Sahl, Jason W.
Webb, Jessica R.
Mayo, Mark
Currie, Bart J.
Podin, Yuwana
Wagner, David M.
Keim, Paul
Schweizer, Herbert P.
Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title_full Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title_fullStr Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title_full_unstemmed Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title_short Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei
title_sort exploring cefiderocol resistance mechanisms in burkholderia pseudomallei
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269091/
https://www.ncbi.nlm.nih.gov/pubmed/37133377
http://dx.doi.org/10.1128/aac.00171-23
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