Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology

The β-lactam antibiotics have been successfully used for decades to combat susceptible Pseudomonas aeruginosa, which has a notoriously difficult to penetrate outer membrane (OM). However, there is a dearth of data on target site penetration and covalent binding of penicillin-binding proteins (PBP) f...

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Detalles Bibliográficos
Autores principales: López-Argüello, Silvia, Montaner, Maria, Sayed, Alaa RM., Oliver, Antonio, Bulitta, Jürgen B., Moya, Bartolome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269149/
https://www.ncbi.nlm.nih.gov/pubmed/37199612
http://dx.doi.org/10.1128/aac.01603-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269149/
https://www.ncbi.nlm.nih.gov/pubmed/37199612
http://dx.doi.org/10.1128/aac.01603-22

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