A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology

Daptomycin is a last-resort antibiotic used for the treatment of infections caused by Gram-positive antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Treatment failure is commonly linked to accumulation of point mutations; however, the contribution of single...

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Detalles Bibliográficos
Autores principales: Xu, Lijuan, Henriksen, Camilla, Mebus, Viktor, Guérillot, Romain, Petersen, Andreas, Jacques, Nicolas, Jiang, Jhih-Hang, Derks, Rico J. E., Sánchez-López, Elena, Giera, Martin, Leeten, Kirsten, Stinear, Timothy P., Oury, Cécile, Howden, Benjamin P., Peleg, Anton Y., Frees, Dorte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269151/
https://www.ncbi.nlm.nih.gov/pubmed/37184389
http://dx.doi.org/10.1128/aac.00328-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269151/
https://www.ncbi.nlm.nih.gov/pubmed/37184389
http://dx.doi.org/10.1128/aac.00328-23

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