A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells

We designed and developed a novel DNA topoisomerase I inhibitor MF-6, which was a more potent cytotoxin and a more potent inducer of immunogenic cell death compared with DXd. To utilize MF-6’s ability to induce antitumor immunity, a human epidermal growth factor receptor 2 (HER2)-targeted antibody–d...

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Detalles Bibliográficos
Autores principales: Tan, Xiaoding, Fang, Peng, Li, Kaiying, You, Meng, Cao, Yuxia, Xu, Hui, Zhu, Xiaohong, Wang, Lu, Wei, Xin, Wen, Haiying, Li, Wendi, Shi, Lei, Sun, Xiaowei, Yu, Dongan, Zhu, Huikai, Wang, Zhenzhen, Liu, Datao, Shen, Hui, Zhou, Wei, An, Maomao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269389/
https://www.ncbi.nlm.nih.gov/pubmed/37314961
http://dx.doi.org/10.1080/19420862.2023.2220466

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