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A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis
Recent evidence emphasized the role of the microbiota in the etiopathogenesis of rheumatoid arthritis (RA). Indeed, it has been demonstrated that urinary tract infections are implicated in RA pathogenesis. However, a definitive association between the urinary tract microbiota and RA remains to be in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269647/ https://www.ncbi.nlm.nih.gov/pubmed/37227288 http://dx.doi.org/10.1128/spectrum.03662-22 |
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author | Jin, Jiayang Li, Jing Hou, Meiling Ding, Xu Zhong, Yan He, Jing Sun, Xiaolin Ye, Hua Li, Ru Wu, Lijun Wang, Jun Guo, Jianping Li, Zhanguo |
author_facet | Jin, Jiayang Li, Jing Hou, Meiling Ding, Xu Zhong, Yan He, Jing Sun, Xiaolin Ye, Hua Li, Ru Wu, Lijun Wang, Jun Guo, Jianping Li, Zhanguo |
author_sort | Jin, Jiayang |
collection | PubMed |
description | Recent evidence emphasized the role of the microbiota in the etiopathogenesis of rheumatoid arthritis (RA). Indeed, it has been demonstrated that urinary tract infections are implicated in RA pathogenesis. However, a definitive association between the urinary tract microbiota and RA remains to be investigated. Urine samples from 39 patients affected by RA, including treatment-naive patients, and 37 age- and sex-matched healthy individuals were collected. In RA patients, the urinary microbiota showed an increase in microbial richness and a decrease in microbial dissimilarity, especially in treatment-naive patients. A total of 48 altered genera with different absolute quantities were detected in patients with RA. The 37 enriched genera included Proteus, Faecalibacterium, and Bacteroides, while the 11 deficient genera included Gardnerella, Ruminococcus, Megasphaera, and Ureaplasma. Notably, the more abundant genera in RA patients were correlated with the disease activity score of 28 joints-erythrocyte sedimentation rates (DAS28-ESR) and an increase in plasma B cells. Furthermore, the altered urinary metabolites, such as proline, citric acid, and oxalic acid, were positively associated with RA patients, and they were closely correlated with urinary microbiota. These findings suggested a strong association between the altered urinary microbiota and metabolites with disease severity and dysregulated immune responses in RA patients. IMPORTANCE We revealed that the profile of the urinary tract microbiota in RA featured with increased microbial richness and shifted taxa, associated with immunological and metabolic changes of the disease, underlining the interplay between urinary microbiota and host autoimmunity. |
format | Online Article Text |
id | pubmed-10269647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-102696472023-06-16 A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis Jin, Jiayang Li, Jing Hou, Meiling Ding, Xu Zhong, Yan He, Jing Sun, Xiaolin Ye, Hua Li, Ru Wu, Lijun Wang, Jun Guo, Jianping Li, Zhanguo Microbiol Spectr Research Article Recent evidence emphasized the role of the microbiota in the etiopathogenesis of rheumatoid arthritis (RA). Indeed, it has been demonstrated that urinary tract infections are implicated in RA pathogenesis. However, a definitive association between the urinary tract microbiota and RA remains to be investigated. Urine samples from 39 patients affected by RA, including treatment-naive patients, and 37 age- and sex-matched healthy individuals were collected. In RA patients, the urinary microbiota showed an increase in microbial richness and a decrease in microbial dissimilarity, especially in treatment-naive patients. A total of 48 altered genera with different absolute quantities were detected in patients with RA. The 37 enriched genera included Proteus, Faecalibacterium, and Bacteroides, while the 11 deficient genera included Gardnerella, Ruminococcus, Megasphaera, and Ureaplasma. Notably, the more abundant genera in RA patients were correlated with the disease activity score of 28 joints-erythrocyte sedimentation rates (DAS28-ESR) and an increase in plasma B cells. Furthermore, the altered urinary metabolites, such as proline, citric acid, and oxalic acid, were positively associated with RA patients, and they were closely correlated with urinary microbiota. These findings suggested a strong association between the altered urinary microbiota and metabolites with disease severity and dysregulated immune responses in RA patients. IMPORTANCE We revealed that the profile of the urinary tract microbiota in RA featured with increased microbial richness and shifted taxa, associated with immunological and metabolic changes of the disease, underlining the interplay between urinary microbiota and host autoimmunity. American Society for Microbiology 2023-05-25 /pmc/articles/PMC10269647/ /pubmed/37227288 http://dx.doi.org/10.1128/spectrum.03662-22 Text en Copyright © 2023 Jin et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Jin, Jiayang Li, Jing Hou, Meiling Ding, Xu Zhong, Yan He, Jing Sun, Xiaolin Ye, Hua Li, Ru Wu, Lijun Wang, Jun Guo, Jianping Li, Zhanguo A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title | A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title_full | A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title_fullStr | A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title_full_unstemmed | A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title_short | A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis |
title_sort | shifted urinary microbiota associated with disease activity and immune responses in rheumatoid arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269647/ https://www.ncbi.nlm.nih.gov/pubmed/37227288 http://dx.doi.org/10.1128/spectrum.03662-22 |
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