Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus

A bedaquiline-resistant Mycobacterium abscessus isolate was sequenced, and a candidate mutation in the atpE gene was identified as responsible for the antibiotic resistance phenotype. To establish a direct genotype-phenotype relationship of this mutation which results in a Asp-to-Ala change at posit...

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Detalles Bibliográficos
Autores principales: Calvet-Seral, Juan, Crespo-Yuste, Estefanía, Mathys, Vanessa, Rodriguez-Villalobos, Hector, Ceyssens, Pieter-Jan, Martin, Anandi, Gonzalo-Asensio, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Methods and Protocols
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269753/
https://www.ncbi.nlm.nih.gov/pubmed/36988496
http://dx.doi.org/10.1128/spectrum.05344-22

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