The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways

Coronaviruses (CoVs), including severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and SARS-CoV-2, produce double-stranded RNA (dsRNA) that activates antiviral pathways such as PKR and OAS/RNase L. To successfully replicate in hosts, viruses must evade...

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Detalles Bibliográficos
Autores principales: LeBlanc, Kyle, Lynch, Jessie, Layne, Christine, Vendramelli, Robert, Sloan, Angela, Tailor, Nikesh, Deschambault, Yvon, Zhang, Fushun, Kobasa, Darwyn, Safronetz, David, Xiang, Yan, Cao, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269842/
https://www.ncbi.nlm.nih.gov/pubmed/37154717
http://dx.doi.org/10.1128/spectrum.00994-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269842/
https://www.ncbi.nlm.nih.gov/pubmed/37154717
http://dx.doi.org/10.1128/spectrum.00994-23

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