Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation

Biosynthesis of the Pel exopolysaccharide in Pseudomonas aeruginosa requires all seven genes of the pelABCDEFG operon. The periplasmic modification enzyme PelA contains a C-terminal deacetylase domain that is necessary for Pel-dependent biofilm formation. Herein, we show that extracellular Pel is no...

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Detalles Bibliográficos
Autores principales: Razvi, Erum, DiFrancesco, Benjamin R., Wasney, Gregory A., Morrison, Zachary A., Tam, John, Auger, Anick, Baker, Perrin, Alnabelseya, Noor, Rich, Jacquelyn D., Sivarajah, Piyanka, Whitfield, Gregory B., Harrison, Joe J., Melnyk, Roman A., Nitz, Mark, Howell, P. Lynne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269871/
https://www.ncbi.nlm.nih.gov/pubmed/37098898
http://dx.doi.org/10.1128/spectrum.00296-23

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