Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins

The antimalarial activity of the frontline drug artemisinin involves generation of reactive oxygen species (ROS) leading to oxidative damage of parasite proteins. To achieve homeostasis and maintain protein quality control in the overwhelmed parasite, the ubiquitin-proteasome system kicks in. Even t...

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Detalles Bibliográficos
Autores principales: Pires, Camilla Valente, Oberstaller, Jenna, Wang, Chengqi, Casandra, Debora, Zhang, Min, Chawla, Jyotsna, Adapa, Swamy Rakesh, Otto, Thomas D., Ferdig, Michael T., Rayner, Julian C., Jiang, Rays H. Y., Adams, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269874/
https://www.ncbi.nlm.nih.gov/pubmed/37067430
http://dx.doi.org/10.1128/spectrum.05014-22

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