SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA

Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the host DNA damage response (DDR). The HBV core protein mediates...

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Detalles Bibliográficos
Autores principales: Hofmann, Samuel, Plank, Verena, Groitl, Peter, Skvorc, Nathalie, Hofmann, Katharina, Luther, Julius, Ko, Chunkyu, Zimmerman, Peter, Bruss, Volker, Stadler, Daniela, Carpentier, Arnaud, Rezk, Shahinda, Nassal, Michael, Protzer, Ulrike, Schreiner, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269885/
https://www.ncbi.nlm.nih.gov/pubmed/37199632
http://dx.doi.org/10.1128/spectrum.00446-23

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