Full Profiling of GE81112A, an Underexplored Tetrapeptide Antibiotic with Activity against Gram-Negative Pathogens

After the first total synthesis combined with structure revision, we performed thorough in vitro and in vivo profiling of the underexplored tetrapeptide GE81112A. From the determination of the biological activity spectrum and physicochemical and early absorption-distribution-metabolism-excretion-tox...

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Detalles Bibliográficos
Autores principales: Schuler, Sören M. M., Jürjens, Gerrit, Marker, Alexander, Hemmann, Ulrike, Rey, Astrid, Yvon, Stéphane, Lagrevol, Marjorie, Hamiti, Mohamed, Nguyen, Fabian, Hirsch, Rolf, Pöverlein, Christoph, Vilcinskas, Andreas, Hammann, Peter, Wilson, Daniel N., Mourez, Michael, Coyne, Sebastien, Bauer, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269895/
https://www.ncbi.nlm.nih.gov/pubmed/37140391
http://dx.doi.org/10.1128/spectrum.02247-22

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