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Role of the proline-rich disordered domain of DROSHA in intronic microRNA processing

DROSHA serves as a gatekeeper of the microRNA (miRNA) pathway by processing primary transcripts (pri-miRNAs). While the functions of structured domains of DROSHA have been well documented, the contribution of N-terminal proline-rich disordered domain (PRD) remains elusive. Here we show that the PRD...

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Detalles Bibliográficos
Autores principales:	Son, Soomin, Kim, Baekgyu, Yang, Jihye, Kim, V. Narry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2023
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270192/ https://www.ncbi.nlm.nih.gov/pubmed/37236670 http://dx.doi.org/10.1101/gad.350275.122

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