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Designer genes courtesy of artificial intelligence
The core promoter determines not only where gene transcription initiates but also the transcriptional activity in both basal and enhancer-induced conditions. Multiple short sequence elements within the core promoter have been identified in different species, but how they function together and to wha...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270197/ https://www.ncbi.nlm.nih.gov/pubmed/37253615 http://dx.doi.org/10.1101/gad.350783.123 |
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author | Hoffmann, Alexander |
author_facet | Hoffmann, Alexander |
author_sort | Hoffmann, Alexander |
collection | PubMed |
description | The core promoter determines not only where gene transcription initiates but also the transcriptional activity in both basal and enhancer-induced conditions. Multiple short sequence elements within the core promoter have been identified in different species, but how they function together and to what extent they are truly species-specific has remained unclear. In this issue of Genes & Development, Vo ngoc and colleagues (pp. 377–382) report undertaking massively parallel measurements of synthetic core promoters to generate a large data set of their activities that informs a statistical learning model to identify the sequence differences of human and Drosophila core promoters. This machine learning model was then applied to design gene core promoters that are particularly specific for the human transcriptional machinery. |
format | Online Article Text |
id | pubmed-10270197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-102701972023-06-16 Designer genes courtesy of artificial intelligence Hoffmann, Alexander Genes Dev Outlook The core promoter determines not only where gene transcription initiates but also the transcriptional activity in both basal and enhancer-induced conditions. Multiple short sequence elements within the core promoter have been identified in different species, but how they function together and to what extent they are truly species-specific has remained unclear. In this issue of Genes & Development, Vo ngoc and colleagues (pp. 377–382) report undertaking massively parallel measurements of synthetic core promoters to generate a large data set of their activities that informs a statistical learning model to identify the sequence differences of human and Drosophila core promoters. This machine learning model was then applied to design gene core promoters that are particularly specific for the human transcriptional machinery. Cold Spring Harbor Laboratory Press 2023-05-01 /pmc/articles/PMC10270197/ /pubmed/37253615 http://dx.doi.org/10.1101/gad.350783.123 Text en © 2023 Hoffmann; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Outlook Hoffmann, Alexander Designer genes courtesy of artificial intelligence |
title | Designer genes courtesy of artificial intelligence |
title_full | Designer genes courtesy of artificial intelligence |
title_fullStr | Designer genes courtesy of artificial intelligence |
title_full_unstemmed | Designer genes courtesy of artificial intelligence |
title_short | Designer genes courtesy of artificial intelligence |
title_sort | designer genes courtesy of artificial intelligence |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270197/ https://www.ncbi.nlm.nih.gov/pubmed/37253615 http://dx.doi.org/10.1101/gad.350783.123 |
work_keys_str_mv | AT hoffmannalexander designergenescourtesyofartificialintelligence |