Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

Cardiac-specific myosin light chain kinase (cMLCK), encoded by MYLK3, regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the pathophysiological and therapeutic implications of cMLCK in human heart failure remain unclear. We aimed to investi...

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Detalles Bibliográficos
Autores principales: Hitsumoto, Tatsuro, Tsukamoto, Osamu, Matsuoka, Ken, Li, Junjun, Liu, Li, Kuramoto, Yuki, Higo, Shuichiro, Ogawa, Shou, Fujino, Noboru, Yoshida, Shohei, Kioka, Hidetaka, Kato, Hisakazu, Hakui, Hideyuki, Saito, Yuki, Okamoto, Chisato, Inoue, Hijiri, Hyejin, Jo, Ueda, Kyoko, Segawa, Takatsugu, Nishimura, Shunsuke, Asano, Yoshihiro, Asanuma, Hiroshi, Tani, Akiyoshi, Imamura, Riyo, Komagawa, Shinsuke, Kanai, Toshio, Takamura, Masayuki, Sakata, Yasushi, Kitakaze, Masafumi, Haruta, Jun-ichi, Takashima, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270284/
https://www.ncbi.nlm.nih.gov/pubmed/37128901
http://dx.doi.org/10.1161/CIRCULATIONAHA.122.062885

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