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The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia

Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared the clinical characteristics and laboratory parameters of coronavirus disease 2019 (COVID-19) patients with and without DM and estimated the effect of DM on mortality among...

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Autores principales: Kusumawati, Maya, Koesoemadinata, Raspati Cundarani, Fatma, Zuhaira Husna, Susandi, Evan, Permana, Hikmat, Soetedjo, Nanny Natalia Mulyani, Soeroto, Arto Yuwono, Bestari, Begawan, Andriyoko, Basti, Alisjahbana, Bachti, Hartantri, Yovita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270330/
https://www.ncbi.nlm.nih.gov/pubmed/37319126
http://dx.doi.org/10.1371/journal.pone.0286797
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author Kusumawati, Maya
Koesoemadinata, Raspati Cundarani
Fatma, Zuhaira Husna
Susandi, Evan
Permana, Hikmat
Soetedjo, Nanny Natalia Mulyani
Soeroto, Arto Yuwono
Bestari, Begawan
Andriyoko, Basti
Alisjahbana, Bachti
Hartantri, Yovita
author_facet Kusumawati, Maya
Koesoemadinata, Raspati Cundarani
Fatma, Zuhaira Husna
Susandi, Evan
Permana, Hikmat
Soetedjo, Nanny Natalia Mulyani
Soeroto, Arto Yuwono
Bestari, Begawan
Andriyoko, Basti
Alisjahbana, Bachti
Hartantri, Yovita
author_sort Kusumawati, Maya
collection PubMed
description Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared the clinical characteristics and laboratory parameters of coronavirus disease 2019 (COVID-19) patients with and without DM and estimated the effect of DM on mortality among COVID-19 patients. A retrospective cohort study collecting patients’ demographic, clinical characteristics, laboratory parameters and treatment outcomes from medical records was conducted in a hospital in Bandung City from March to December 2020. Univariable and multivariable logistic regression was performed to determine the association between DM and death. A total of 664 COVID-19 patients with positive real-time reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 were included in this study, of whom 147 were with DM. Half of DM patients presented HbA1c ≥10%. DM patients were more likely to present with comorbidities and severe to critical conditions at admission (P <0.001). Laboratory parameters such as neutrophil-lymphocyte count ratio, C-reactive protein, D-dimer, ferritin, and lactate dehydrogenase were higher in the DM group. In the univariate analysis, variables associated with death were COVID-19 severity at baseline, neurologic disease, DM, age ≥60 years, hypertension, cardiovascular disease, and chronic kidney disease. DM remained associated with death (aOR 1.82; 95% CI 1.13–2.93) after adjustment with sex, age, hypertension, cardiovascular disease, and chronic kidney disease. In conclusion, COVID-19 patients with DM are more likely to present with a very high HbA1c, comorbidities, and severe-critical illness. Chronic inflammation in DM patients may be aggravated by the disruption of immune response caused by COVID-19, leading to worse laboratory results and poor outcomes.
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spelling pubmed-102703302023-06-16 The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia Kusumawati, Maya Koesoemadinata, Raspati Cundarani Fatma, Zuhaira Husna Susandi, Evan Permana, Hikmat Soetedjo, Nanny Natalia Mulyani Soeroto, Arto Yuwono Bestari, Begawan Andriyoko, Basti Alisjahbana, Bachti Hartantri, Yovita PLoS One Research Article Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared the clinical characteristics and laboratory parameters of coronavirus disease 2019 (COVID-19) patients with and without DM and estimated the effect of DM on mortality among COVID-19 patients. A retrospective cohort study collecting patients’ demographic, clinical characteristics, laboratory parameters and treatment outcomes from medical records was conducted in a hospital in Bandung City from March to December 2020. Univariable and multivariable logistic regression was performed to determine the association between DM and death. A total of 664 COVID-19 patients with positive real-time reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 were included in this study, of whom 147 were with DM. Half of DM patients presented HbA1c ≥10%. DM patients were more likely to present with comorbidities and severe to critical conditions at admission (P <0.001). Laboratory parameters such as neutrophil-lymphocyte count ratio, C-reactive protein, D-dimer, ferritin, and lactate dehydrogenase were higher in the DM group. In the univariate analysis, variables associated with death were COVID-19 severity at baseline, neurologic disease, DM, age ≥60 years, hypertension, cardiovascular disease, and chronic kidney disease. DM remained associated with death (aOR 1.82; 95% CI 1.13–2.93) after adjustment with sex, age, hypertension, cardiovascular disease, and chronic kidney disease. In conclusion, COVID-19 patients with DM are more likely to present with a very high HbA1c, comorbidities, and severe-critical illness. Chronic inflammation in DM patients may be aggravated by the disruption of immune response caused by COVID-19, leading to worse laboratory results and poor outcomes. Public Library of Science 2023-06-15 /pmc/articles/PMC10270330/ /pubmed/37319126 http://dx.doi.org/10.1371/journal.pone.0286797 Text en © 2023 Kusumawati et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kusumawati, Maya
Koesoemadinata, Raspati Cundarani
Fatma, Zuhaira Husna
Susandi, Evan
Permana, Hikmat
Soetedjo, Nanny Natalia Mulyani
Soeroto, Arto Yuwono
Bestari, Begawan
Andriyoko, Basti
Alisjahbana, Bachti
Hartantri, Yovita
The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title_full The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title_fullStr The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title_full_unstemmed The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title_short The effect of diabetes mellitus on COVID-19 mortality among patients in a tertiary-level hospital in Bandung, Indonesia
title_sort effect of diabetes mellitus on covid-19 mortality among patients in a tertiary-level hospital in bandung, indonesia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270330/
https://www.ncbi.nlm.nih.gov/pubmed/37319126
http://dx.doi.org/10.1371/journal.pone.0286797
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