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A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia
BACKGROUND: The Al-Kharj colorectal cancer (CRC) screening program was implemented for five years (2017-2022) in a central urban area of Riyadh Province, Saudi Arabia, to assess the participation and impact of the program in average-risk individuals. METHODS: The high sensitivity-guaiac based-fecal...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270470/ https://www.ncbi.nlm.nih.gov/pubmed/36254929 http://dx.doi.org/10.4103/sjg.sjg_333_22 |
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author | Zacharakis, Georgios Almasoud, Abdulaziz Arahmaner, Omar Aldossary, Khaled Alzahrani, Jamaan Al-Ghamdi, Sameer AlShehri, Abdullah Nikolaidis, Pavlos Bawazir, Abdullah Alfayez, Talal Daadour, Moataz Alslimah, Faisal Altamimi, Mohammed Alshalawi, Sami |
author_facet | Zacharakis, Georgios Almasoud, Abdulaziz Arahmaner, Omar Aldossary, Khaled Alzahrani, Jamaan Al-Ghamdi, Sameer AlShehri, Abdullah Nikolaidis, Pavlos Bawazir, Abdullah Alfayez, Talal Daadour, Moataz Alslimah, Faisal Altamimi, Mohammed Alshalawi, Sami |
author_sort | Zacharakis, Georgios |
collection | PubMed |
description | BACKGROUND: The Al-Kharj colorectal cancer (CRC) screening program was implemented for five years (2017-2022) in a central urban area of Riyadh Province, Saudi Arabia, to assess the participation and impact of the program in average-risk individuals. METHODS: The high sensitivity-guaiac based-fecal occult blood test (HSgFOBT) was used as a first-line investigation to identify asymptomatic patients, aged 45–75 years, requiring CRC screening using colonoscopy. The program was run in three tertiary hospitals in the area. RESULTS: The five-year participation rate was 73% (35,640/48,897). The average age was 53 years (range 45–75), 49% were female (17,464/35,640), all were asymptomatic, and 77% had adequate bowel preparation. The HSgFOBT (+) rate was 6.3% (n = 2245), and 76% (n = 1701) of these underwent colonoscopy. The prevalence of findings were as follows: CRC, 4.8% (81/1701); advanced adenoma, 9.5% (162/1701); adenoma, 15.9% (270/1701); non-adenomatous polyps, 7.9% (135/1701); and no polyps or tumors, 25.4% (432/1701). Among participants aged 45–50 years, early onset-CRC had female predominance, while those ≥50 years with late onset-CRC were predominantly male. CRC was more prevalent in the left colon (P < 0.005). CONCLUSIONS: Approximately one-third of the participants diagnosed with CRC had early-onset CRC. Screening participation was desirable for the defined target population. Public education is necessary along with expanded colonoscopy resources to continue further citizen participation. |
format | Online Article Text |
id | pubmed-10270470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102704702023-06-16 A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia Zacharakis, Georgios Almasoud, Abdulaziz Arahmaner, Omar Aldossary, Khaled Alzahrani, Jamaan Al-Ghamdi, Sameer AlShehri, Abdullah Nikolaidis, Pavlos Bawazir, Abdullah Alfayez, Talal Daadour, Moataz Alslimah, Faisal Altamimi, Mohammed Alshalawi, Sami Saudi J Gastroenterol Original Article BACKGROUND: The Al-Kharj colorectal cancer (CRC) screening program was implemented for five years (2017-2022) in a central urban area of Riyadh Province, Saudi Arabia, to assess the participation and impact of the program in average-risk individuals. METHODS: The high sensitivity-guaiac based-fecal occult blood test (HSgFOBT) was used as a first-line investigation to identify asymptomatic patients, aged 45–75 years, requiring CRC screening using colonoscopy. The program was run in three tertiary hospitals in the area. RESULTS: The five-year participation rate was 73% (35,640/48,897). The average age was 53 years (range 45–75), 49% were female (17,464/35,640), all were asymptomatic, and 77% had adequate bowel preparation. The HSgFOBT (+) rate was 6.3% (n = 2245), and 76% (n = 1701) of these underwent colonoscopy. The prevalence of findings were as follows: CRC, 4.8% (81/1701); advanced adenoma, 9.5% (162/1701); adenoma, 15.9% (270/1701); non-adenomatous polyps, 7.9% (135/1701); and no polyps or tumors, 25.4% (432/1701). Among participants aged 45–50 years, early onset-CRC had female predominance, while those ≥50 years with late onset-CRC were predominantly male. CRC was more prevalent in the left colon (P < 0.005). CONCLUSIONS: Approximately one-third of the participants diagnosed with CRC had early-onset CRC. Screening participation was desirable for the defined target population. Public education is necessary along with expanded colonoscopy resources to continue further citizen participation. Wolters Kluwer - Medknow 2022-10-06 /pmc/articles/PMC10270470/ /pubmed/36254929 http://dx.doi.org/10.4103/sjg.sjg_333_22 Text en Copyright: © 2022 Saudi Journal of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Zacharakis, Georgios Almasoud, Abdulaziz Arahmaner, Omar Aldossary, Khaled Alzahrani, Jamaan Al-Ghamdi, Sameer AlShehri, Abdullah Nikolaidis, Pavlos Bawazir, Abdullah Alfayez, Talal Daadour, Moataz Alslimah, Faisal Altamimi, Mohammed Alshalawi, Sami A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title | A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title_full | A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title_fullStr | A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title_full_unstemmed | A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title_short | A 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in Central Saudi Arabia |
title_sort | 5-year evaluation of early-and late-onset sporadic colorectal cancer screening in central saudi arabia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270470/ https://www.ncbi.nlm.nih.gov/pubmed/36254929 http://dx.doi.org/10.4103/sjg.sjg_333_22 |
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