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Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis

Adeno-associated virus (AAV) plays a vital role in ocular gene therapy and has been widely studied since 1996. This study summarizes and explores the publication outputs and future research trends of AAV-based ocular gene therapy. METHODS: Publications and data about AAV-based ocular gene therapy we...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Yu, Yang, Nie, Huiling, Qin, Xun, Bai, Wen, Ren, Junsong, Yao, Jin, Li, Juxue, Jiang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270495/
https://www.ncbi.nlm.nih.gov/pubmed/37327269
http://dx.doi.org/10.1097/MD.0000000000034043
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author Chen, Xi
Yu, Yang
Nie, Huiling
Qin, Xun
Bai, Wen
Ren, Junsong
Yao, Jin
Li, Juxue
Jiang, Qin
author_facet Chen, Xi
Yu, Yang
Nie, Huiling
Qin, Xun
Bai, Wen
Ren, Junsong
Yao, Jin
Li, Juxue
Jiang, Qin
author_sort Chen, Xi
collection PubMed
description Adeno-associated virus (AAV) plays a vital role in ocular gene therapy and has been widely studied since 1996. This study summarizes and explores the publication outputs and future research trends of AAV-based ocular gene therapy. METHODS: Publications and data about AAV-based ocular gene therapy were downloaded from the Web of Science Core Collection or ClinicalTrials.gov database. The publications and data were analyzed by Microsoft Excel, CiteSpace, VOS viewer, and a free online platform (http://bibliometric.com). RESULTS: Totally 832 publications from the Web of Science Core Collection relevant to AAV-based ocular gene therapy were published from 1996 to 2022. These publications were contributed by research institutes from 42 countries or regions. The US contributed the most publications among these countries or regions, notably the University of Florida. Hauswirth WW was the most productive author. “Efficacy” and “safety” are the main focus areas for future research according to the references and keywords analysis. Eighty clinical trials examined AAV-based ocular gene therapy were registered on ClinicalTrials.Gov. Institutes from the US and European did the dominant number or the large proportion of the trials. CONCLUSIONS: The research focus of the AAV-based ocular gene therapy has transitioned from the study in biological theory to clinical trialing. The AAV-based gene therapy is not limited to inherited retinal diseases but various ocular diseases.
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spelling pubmed-102704952023-06-16 Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis Chen, Xi Yu, Yang Nie, Huiling Qin, Xun Bai, Wen Ren, Junsong Yao, Jin Li, Juxue Jiang, Qin Medicine (Baltimore) 5800 Adeno-associated virus (AAV) plays a vital role in ocular gene therapy and has been widely studied since 1996. This study summarizes and explores the publication outputs and future research trends of AAV-based ocular gene therapy. METHODS: Publications and data about AAV-based ocular gene therapy were downloaded from the Web of Science Core Collection or ClinicalTrials.gov database. The publications and data were analyzed by Microsoft Excel, CiteSpace, VOS viewer, and a free online platform (http://bibliometric.com). RESULTS: Totally 832 publications from the Web of Science Core Collection relevant to AAV-based ocular gene therapy were published from 1996 to 2022. These publications were contributed by research institutes from 42 countries or regions. The US contributed the most publications among these countries or regions, notably the University of Florida. Hauswirth WW was the most productive author. “Efficacy” and “safety” are the main focus areas for future research according to the references and keywords analysis. Eighty clinical trials examined AAV-based ocular gene therapy were registered on ClinicalTrials.Gov. Institutes from the US and European did the dominant number or the large proportion of the trials. CONCLUSIONS: The research focus of the AAV-based ocular gene therapy has transitioned from the study in biological theory to clinical trialing. The AAV-based gene therapy is not limited to inherited retinal diseases but various ocular diseases. Lippincott Williams & Wilkins 2023-06-16 /pmc/articles/PMC10270495/ /pubmed/37327269 http://dx.doi.org/10.1097/MD.0000000000034043 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5800
Chen, Xi
Yu, Yang
Nie, Huiling
Qin, Xun
Bai, Wen
Ren, Junsong
Yao, Jin
Li, Juxue
Jiang, Qin
Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title_full Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title_fullStr Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title_full_unstemmed Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title_short Insights into adeno-associated virus-based ocular gene therapy: A bibliometric and visual analysis
title_sort insights into adeno-associated virus-based ocular gene therapy: a bibliometric and visual analysis
topic 5800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270495/
https://www.ncbi.nlm.nih.gov/pubmed/37327269
http://dx.doi.org/10.1097/MD.0000000000034043
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