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Wilson disease complicated by Crohn disease: A case report and literature review

Wilson disease (WD), also known as hepatolenticular degeneration, is an autosomal-recessive hereditary disease with abnormal copper metabolism. Crohn disease (CD) is a chronic inflammatory gastrointestinal disease, which belongs to inflammatory bowel disease, all segments of the gastrointestinal tra...

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Autores principales: Chen, Minmin, Li, Chenyan, Peng, Shiqiao, Liu, Mengyuan, Li, Yiling, Sun, Mingjun, Sun, Xuren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270515/
https://www.ncbi.nlm.nih.gov/pubmed/37327274
http://dx.doi.org/10.1097/MD.0000000000033839
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author Chen, Minmin
Li, Chenyan
Peng, Shiqiao
Liu, Mengyuan
Li, Yiling
Sun, Mingjun
Sun, Xuren
author_facet Chen, Minmin
Li, Chenyan
Peng, Shiqiao
Liu, Mengyuan
Li, Yiling
Sun, Mingjun
Sun, Xuren
author_sort Chen, Minmin
collection PubMed
description Wilson disease (WD), also known as hepatolenticular degeneration, is an autosomal-recessive hereditary disease with abnormal copper metabolism. Crohn disease (CD) is a chronic inflammatory gastrointestinal disease, which belongs to inflammatory bowel disease, all segments of the gastrointestinal tract can be affected, especially the terminal ileum and colon, accompanied by extraintestinal manifestations and related immune disorders. WD complicated by ulcerative colitis has been reported before, but WD complicated by CD has not been reported so far. PATIENT CONCERNS AND DIAGNOSIS: We presented the first report of a young patient with WD complicated by CD, who was admitted to the hospital because of repeated low fever, elevated C-reactive protein for 3 years, and anal fistula for 6 months. INTERVENTIONS AND OUTCOMES: In this complicated disease, Ustekinumab is safe and effective. LESSONS: We conclude that copper metabolism and oxidative stress play important roles in WD and CD.
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spelling pubmed-102705152023-06-16 Wilson disease complicated by Crohn disease: A case report and literature review Chen, Minmin Li, Chenyan Peng, Shiqiao Liu, Mengyuan Li, Yiling Sun, Mingjun Sun, Xuren Medicine (Baltimore) 4500 Wilson disease (WD), also known as hepatolenticular degeneration, is an autosomal-recessive hereditary disease with abnormal copper metabolism. Crohn disease (CD) is a chronic inflammatory gastrointestinal disease, which belongs to inflammatory bowel disease, all segments of the gastrointestinal tract can be affected, especially the terminal ileum and colon, accompanied by extraintestinal manifestations and related immune disorders. WD complicated by ulcerative colitis has been reported before, but WD complicated by CD has not been reported so far. PATIENT CONCERNS AND DIAGNOSIS: We presented the first report of a young patient with WD complicated by CD, who was admitted to the hospital because of repeated low fever, elevated C-reactive protein for 3 years, and anal fistula for 6 months. INTERVENTIONS AND OUTCOMES: In this complicated disease, Ustekinumab is safe and effective. LESSONS: We conclude that copper metabolism and oxidative stress play important roles in WD and CD. Lippincott Williams & Wilkins 2023-06-16 /pmc/articles/PMC10270515/ /pubmed/37327274 http://dx.doi.org/10.1097/MD.0000000000033839 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4500
Chen, Minmin
Li, Chenyan
Peng, Shiqiao
Liu, Mengyuan
Li, Yiling
Sun, Mingjun
Sun, Xuren
Wilson disease complicated by Crohn disease: A case report and literature review
title Wilson disease complicated by Crohn disease: A case report and literature review
title_full Wilson disease complicated by Crohn disease: A case report and literature review
title_fullStr Wilson disease complicated by Crohn disease: A case report and literature review
title_full_unstemmed Wilson disease complicated by Crohn disease: A case report and literature review
title_short Wilson disease complicated by Crohn disease: A case report and literature review
title_sort wilson disease complicated by crohn disease: a case report and literature review
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270515/
https://www.ncbi.nlm.nih.gov/pubmed/37327274
http://dx.doi.org/10.1097/MD.0000000000033839
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