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Stromal regulation of the intestinal barrier

The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here w...

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Detalles Bibliográficos
Autores principales: Sylvestre, Marvin, Di Carlo, Selene E., Peduto, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270662/
https://www.ncbi.nlm.nih.gov/pubmed/36708806
http://dx.doi.org/10.1016/j.mucimm.2023.01.006
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author Sylvestre, Marvin
Di Carlo, Selene E.
Peduto, Lucie
author_facet Sylvestre, Marvin
Di Carlo, Selene E.
Peduto, Lucie
author_sort Sylvestre, Marvin
collection PubMed
description The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here we review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based gene deletion, and single-cell transcriptomics. The current evidence points toward a key organizer role for distinct mesenchymal lineages in intestinal development and homeostasis, regulating both epithelial and immune components of the intestinal barrier. We further discuss recent findings on functional mesenchymal heterogeneity and implications for intestinal regeneration and inflammatory intestinal pathologies.
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spelling pubmed-102706622023-06-16 Stromal regulation of the intestinal barrier Sylvestre, Marvin Di Carlo, Selene E. Peduto, Lucie Mucosal Immunol Review The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here we review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based gene deletion, and single-cell transcriptomics. The current evidence points toward a key organizer role for distinct mesenchymal lineages in intestinal development and homeostasis, regulating both epithelial and immune components of the intestinal barrier. We further discuss recent findings on functional mesenchymal heterogeneity and implications for intestinal regeneration and inflammatory intestinal pathologies. Elsevier 2023-04 /pmc/articles/PMC10270662/ /pubmed/36708806 http://dx.doi.org/10.1016/j.mucimm.2023.01.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Sylvestre, Marvin
Di Carlo, Selene E.
Peduto, Lucie
Stromal regulation of the intestinal barrier
title Stromal regulation of the intestinal barrier
title_full Stromal regulation of the intestinal barrier
title_fullStr Stromal regulation of the intestinal barrier
title_full_unstemmed Stromal regulation of the intestinal barrier
title_short Stromal regulation of the intestinal barrier
title_sort stromal regulation of the intestinal barrier
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270662/
https://www.ncbi.nlm.nih.gov/pubmed/36708806
http://dx.doi.org/10.1016/j.mucimm.2023.01.006
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