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Stromal regulation of the intestinal barrier
The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270662/ https://www.ncbi.nlm.nih.gov/pubmed/36708806 http://dx.doi.org/10.1016/j.mucimm.2023.01.006 |
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author | Sylvestre, Marvin Di Carlo, Selene E. Peduto, Lucie |
author_facet | Sylvestre, Marvin Di Carlo, Selene E. Peduto, Lucie |
author_sort | Sylvestre, Marvin |
collection | PubMed |
description | The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here we review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based gene deletion, and single-cell transcriptomics. The current evidence points toward a key organizer role for distinct mesenchymal lineages in intestinal development and homeostasis, regulating both epithelial and immune components of the intestinal barrier. We further discuss recent findings on functional mesenchymal heterogeneity and implications for intestinal regeneration and inflammatory intestinal pathologies. |
format | Online Article Text |
id | pubmed-10270662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102706622023-06-16 Stromal regulation of the intestinal barrier Sylvestre, Marvin Di Carlo, Selene E. Peduto, Lucie Mucosal Immunol Review The intestinal barrier is a complex structure that allows the absorption of nutrients while ensuring protection against intestinal pathogens and balanced immunity. The development and maintenance of a functional intestinal barrier is a multifactorial process that is only partially understood. Here we review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based gene deletion, and single-cell transcriptomics. The current evidence points toward a key organizer role for distinct mesenchymal lineages in intestinal development and homeostasis, regulating both epithelial and immune components of the intestinal barrier. We further discuss recent findings on functional mesenchymal heterogeneity and implications for intestinal regeneration and inflammatory intestinal pathologies. Elsevier 2023-04 /pmc/articles/PMC10270662/ /pubmed/36708806 http://dx.doi.org/10.1016/j.mucimm.2023.01.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Sylvestre, Marvin Di Carlo, Selene E. Peduto, Lucie Stromal regulation of the intestinal barrier |
title | Stromal regulation of the intestinal barrier |
title_full | Stromal regulation of the intestinal barrier |
title_fullStr | Stromal regulation of the intestinal barrier |
title_full_unstemmed | Stromal regulation of the intestinal barrier |
title_short | Stromal regulation of the intestinal barrier |
title_sort | stromal regulation of the intestinal barrier |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270662/ https://www.ncbi.nlm.nih.gov/pubmed/36708806 http://dx.doi.org/10.1016/j.mucimm.2023.01.006 |
work_keys_str_mv | AT sylvestremarvin stromalregulationoftheintestinalbarrier AT dicarloselenee stromalregulationoftheintestinalbarrier AT pedutolucie stromalregulationoftheintestinalbarrier |