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Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases
Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undif...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270764/ https://www.ncbi.nlm.nih.gov/pubmed/37332618 http://dx.doi.org/10.1155/2023/8821610 |
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author | Peng, Yuan Zhou, Mengxian Yang, Hong Qu, Ruyi Qiu, Yan Hao, Jiawen Bi, Hongsheng Guo, Dadong |
author_facet | Peng, Yuan Zhou, Mengxian Yang, Hong Qu, Ruyi Qiu, Yan Hao, Jiawen Bi, Hongsheng Guo, Dadong |
author_sort | Peng, Yuan |
collection | PubMed |
description | Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undifferentiated macrophages can polarize into classically activated macrophages (M1 macrophages) and alternatively activated macrophages (M2 macrophages) under different microenvironmental conditions. The directions of macrophage polarization can be regulated by a series of factors, including interferon, lipopolysaccharide, interleukin, and noncoding RNAs. To elucidate the role of macrophages in various autoimmune diseases, we searched the literature on macrophages with the PubMed database. Search terms are as follows: macrophages, polarization, signaling pathways, noncoding RNA, inflammation, autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, lupus nephritis, Sjogren's syndrome, Guillain-Barré syndrome, and multiple sclerosis. In the present study, we summarize the role of macrophage polarization in common autoimmune diseases. In addition, we also summarize the features and recent advances with a particular focus on the immunotherapeutic potential of macrophage polarization in autoimmune diseases and the potentially effective therapeutic targets. |
format | Online Article Text |
id | pubmed-10270764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-102707642023-06-16 Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases Peng, Yuan Zhou, Mengxian Yang, Hong Qu, Ruyi Qiu, Yan Hao, Jiawen Bi, Hongsheng Guo, Dadong Mediators Inflamm Review Article Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undifferentiated macrophages can polarize into classically activated macrophages (M1 macrophages) and alternatively activated macrophages (M2 macrophages) under different microenvironmental conditions. The directions of macrophage polarization can be regulated by a series of factors, including interferon, lipopolysaccharide, interleukin, and noncoding RNAs. To elucidate the role of macrophages in various autoimmune diseases, we searched the literature on macrophages with the PubMed database. Search terms are as follows: macrophages, polarization, signaling pathways, noncoding RNA, inflammation, autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, lupus nephritis, Sjogren's syndrome, Guillain-Barré syndrome, and multiple sclerosis. In the present study, we summarize the role of macrophage polarization in common autoimmune diseases. In addition, we also summarize the features and recent advances with a particular focus on the immunotherapeutic potential of macrophage polarization in autoimmune diseases and the potentially effective therapeutic targets. Hindawi 2023-06-08 /pmc/articles/PMC10270764/ /pubmed/37332618 http://dx.doi.org/10.1155/2023/8821610 Text en Copyright © 2023 Yuan Peng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Peng, Yuan Zhou, Mengxian Yang, Hong Qu, Ruyi Qiu, Yan Hao, Jiawen Bi, Hongsheng Guo, Dadong Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title_full | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title_fullStr | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title_full_unstemmed | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title_short | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
title_sort | regulatory mechanism of m1/m2 macrophage polarization in the development of autoimmune diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270764/ https://www.ncbi.nlm.nih.gov/pubmed/37332618 http://dx.doi.org/10.1155/2023/8821610 |
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