Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study

INTRODUCTION: Kukoamine B (KB) is a novel sepsis therapeutic drug targeting lipopolysaccharide and CpG DNA. This study aims to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of multiple doses of KB in healthy volunteers. METHODS: Healthy volunteers were randomized at a 1:1:1:1 r...

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Detalles Bibliográficos
Autores principales: Zhao, Qian, Liu, Hongzhong, Wang, Zhenlei, Wang, Teng, Cui, Cheng, Wang, Huanhuan, Li, Lili, Zhong, Wen, Jiang, Ji, Dong, Kai, Chen, Shuai, Jin, Chunyan, Hu, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10271881/
https://www.ncbi.nlm.nih.gov/pubmed/37233875
http://dx.doi.org/10.1007/s12325-023-02521-1

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